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Though scientists have struggled to understand why some people appear to be more vulnerable to addiction than others, one popular theory is that these temporary effects eventually cause the brain to lose its ability to regulate dopamine levels

Several upstream signals of abnormal mitochondrial dynamics have been described in the setting of DCM, including translocase of outer mitochondrial membrane 70 (Tom70) [121], cyclin C [122], sirtuin 1 (Sirt1) [123], estrogen [124], Gp78 [125], insulin [126] and norepinephrine [127]

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